The effect of grapefruit juice on drug disposition
نویسندگان
چکیده
منابع مشابه
Grapefruit juice-drug interactions.
The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation from an interaction study between the dihydropyridine calcium channel antagonist, felodipine, and ethanol in which grapefruit juice was used to mask the taste of the ethanol. Subsequent investigations showed that grapefruit juice acted by reducing presystemic felodipine ...
متن کاملFurther characterization of a furanocoumarin-free grapefruit juice on drug disposition: studies with cyclosporine.
BACKGROUND We previously established furanocoumarins as mediators of the interaction between grapefruit juice (GFJ) and the model CYP3A4 substrate felodipine in healthy volunteers using a GFJ devoid of furanocoumarins. It remains unclear whether furanocoumarins mediate drug-GFJ interactions involving CYP3A4 substrates that are also P-glycoprotein substrates. OBJECTIVE The effects of furanocou...
متن کاملOral midazolam-grapefruit juice drug interaction.
Oral midazolam is a frequently used sedative in pediatric dentistry. Although an oral form of midazolam is now commercially available, some practitioners continue to use the IV midazolam as an oral medication. If the injectible form of midazolam is administered orally, its bitter taste requires the use of a flavoring agent. Grapefruit juice is contraindicated for this purpose as it inhibits cyt...
متن کاملEffect of grapefruit juice on bioavailability of montelukast.
OBJECTIVES/HYPOTHESIS The aim of this study was to investigate possible interactions between grapefruit juice and montelukast for up to 4 hours. STUDY DESIGN A prospective, crossover study with 23 healthy volunteers was performed in two sessions. METHODS In the first session, volunteers were treated with oral montelukast 10 mg once daily with 250 ml water. After a 10-day washout period, the...
متن کاملthe washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests
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ژورنال
عنوان ژورنال: Expert Opinion on Drug Metabolism & Toxicology
سال: 2011
ISSN: 1742-5255,1744-7607
DOI: 10.1517/17425255.2011.553189